老虎机永利

search for:
Prof. Jun Jun from Sun Yat-sen University's group "Adv. Funct. Mater.": New Progress in Research of Therapeutic Biodegradable Polymers
2019-12-28 Source: Polymer Technology

At present, the research on the use of polymers to build nano-drug delivery systems is mainly limited to a small number of polyesters such as PLA, PLGA, and PCL. These polymers and their degradation products do not have any therapeutic effect by themselves, and sometimes bring additional side effects. Therefore, if the polymer itself can provide additional therapeutic effects, it will be a promising drug carrier material. Many natural small molecule compounds derived from plants have unique biological activities. If they are further developed into biomedical materials with therapeutic effects, they will provide a new way for the innovation of new medical materials.

Ursolic acid (UA) is an active ingredient widely distributed in Chinese herbal medicines. It has various biological effects such as sedation, anti-inflammatory, anti-oxidation, anti-cancer, and liver protection. Recently, Professor Wu Jun's team at Sun Yat-sen University aimed to develop a biosafety nano-carrier with its own anti-cancer properties. It innovatively selected ursolic acid as a repeating structural unit, and synthesized a synthetic anti-tumor agent in a simple and quick way. An active biodegradable polymer, poly-ursolic acid (PUA), and self-assembled into nanoparticles as an anti-cancer drug delivery platform (PUA-NPs). The prepared drug-loading nano drug delivery system (PUA-NPs @ PTX) has a suitable particle size and a high drug loading capacity. The results in vitro and in vivo show that PUA-NPs @ PTX can significantly inhibit colorectal cancer. At the same time, Blank PUA-NPs can also inhibit tumor growth, indicating that PUA itself has anticancer activity. This new polymer nanocarrier provides new ideas for the development of new active biomaterials, and also provides a promising method for the treatment of colorectal cancer and other cancers, and has a good prospect of clinical transformation.

This achievement, entitled "Nanodrug Carrier Based on Poly (Ursolic Acid) with Self-Anticancer Activity against Colorectal Cancer", was recently published online in Advanced Functional Materials (DOI: 10.1002 / adfm.201907857, Adv. Funct. Mater. 2019, 1907857), Qu Kunyong, Xu Xiaojun and Guan Shuyu are the first authors, Professor Wu Jun is the corresponding author, Kang Yang is an associate researcher and the co-corresponding author, and Sun Yat-sen University is the first and corresponding unit. This research work has received strong support from the National Key Research and Development Plan, the National Natural Science Foundation of China, the Innovation Team of Guangdong Province, and the Science and Technology Plan of Guangzhou.

Article link: http://onlinelibrary.wiley.com/doi/pdf/10.1002/adfm.201907857

Copyright and Disclaimer: Original article from China Polymer Network. For reprinting of publications or media, please contact the email address : info@chevronsz.com , and please indicate the source.
(Responsible editor: xu)

Invited to pay attention to polymer technology

最新资讯 More >> Latest News
科教新闻 More >> Science and Education News
永利娱乐资讯 ag体育 球探体育平台登录 葡京app官网 足球平台 ag平台游戏老虎机永利 亚博登录网站 皇冠体育网站 188体育 沙巴体育平台官方投注